Tin-protoporphyrin suppression of hyperbilirubinemia in mutant mice with severe hemolytic anemia
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Tin-protoporphyrin suppression of hyperbilirubinemia in mutant mice with severe hemolytic anemia.
Tin-protoporphyrin is a potent competitive inhibitor of heme oxygenase both in vivo in animals and in vitro in isolated enzyme preparations, and when administered to neonatal rats, prevents the development of postnatal hyperbilirubinemia. In this study we examined the effect of the metalloporphyrin on the activity of heme oxygenase in liver, kidney, and spleen, and on the level of bilirubin in ...
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ژورنال
عنوان ژورنال: Blood
سال: 1983
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v61.5.1011.1011