Timed daily exercise remodels circadian rhythms in mice

Abstract Regular exercise is important for physical and mental health. An underexplored intriguing property of its actions on the body’s 24 h or circadian rhythms. Molecular clock cells in brain’s suprachiasmatic nuclei (SCN) use electrical chemical signals to orchestrate their activity convey time day information rest brain body. To date, long-lasting effects regular SCN cell coordination communication remain unresolved. Utilizing mouse models which intercellular neuropeptide signaling impaired as well those with intact neurochemical signaling, we examined how daily scheduled voluntary (SVE) influenced behavioral rhythms molecular neuronal activities. We show that mice disrupted SVE promotes synchrony robust behavior. Interestingly, both deficient animals, reduces neural alters GABAergic signaling. These findings illustrate potential utility a effective non-invasive intervention elderly mentally ill where can be blunted poorly aligned external world.