Time to Turn Up the Volume

Time to turn up the HEAT?

In a lifetime of observing and participating in politics, the world wide campaign by the international green movement (aided by the power-seeking UN bureaucracy) to monitor, control and tax every food, energy and transport business in the world is the most dangerous development I have ever seen. It has the potential to blight the lives and investments of the majority of Australians who are unab...

To the Framingham data, turn, turn, turn.

Evolution: A Turn Up for the Worms

Extensive sequencing of transcriptomes reveals the evolutionary relationships among the major flatworm lineages, suggesting new roots and conflicting routes to parasitism.

How to Turn the Reaction Coordinate into Time

What are the internal motions of an ion channel protein when it “gates” between closed and open-channel conformations? In 2005, Zhou, Pearson, and Auerbach (ZPA) (Biophys. J. 89:3680–3685) showed that Φ, a parameter derived from the forward and backward rate constants of a chemical reaction, may in some cases provide temporal information about the moving parts of a protein. This “primer” is int...

Simply the right time to turn on insulin.

D iabetes mellitus is a metabolic disorder of multiple etiology characterized by chronic hyperglycemia, which over time leads to long-term damage, dysfunction, and failure of various organs (American Diabetes Association, 2013). Finding ways to restore the pancreatic beta cell population in patients with type 1 diabetes, or replace dysfunctional beta cells in patients with type 2 disease, remai...