Time to play Catch-Up

Emergency medicine in South Africa - time to catch up.

Play down protein to play up metabolism?

Who among us hasn't fantasized about a diet that allows ingestion of a surfeit of calories that are burned off effortlessly by ramping up energy expenditure? In this issue of the JCI, research led by Christopher Morrison suggests that this dream may become a reality; however, a complete understanding of the molecular interface that connects nutrient choices with our cellular metabolism will be ...

Statistics catch-up lecture

Example 1. In a genetic study, n = 2217 patients are recruited, among which 1127 have bladder cancer. After whole genome sequencing, p = 475290 single nucleatide polymorphisms (or SNPs, a possible variation of the DNA sequence at one location) are measured on each patient. We construct a matrix X = (Xij)1≤i≤n,1≤j≤p where Xij = 1 if the ith patient has a mutation at jth location and 0 otherwise....

Catch-up Growth

Catch-up growth.

Catch-up growth, defined as growth velocity above the statistical limits of normality for age or maturity during a defined period of time, is distinguished from compensatory growth since it makes up for a potential loss rather than an actual loss and is seen in the whole body as opposed to specific organs. The cellular explanation for catch-up based on the work of Winick is described and a rece...