Time-resolved force distribution analysis

Time-resolved force distribution analysis

BACKGROUND Biomolecules or other complex macromolecules undergo conformational transitions upon exposure to an external perturbation such as ligand binding or mechanical force. To follow fluctuations in pairwise forces between atoms or residues during such conformational changes as observed in Molecular Dynamics (MD) simulations, we developed Time-Resolved Force Distribution Analysis (TRFDA). ...

Size Distribution Measurement of Candle\'s Soot Nanoparticles by Using Time Resolved Laser Induced Incandescence

Time resolved laser induced incandescence (LII) technique is used to measure size distribution of soot nanoparticles of candle's flame. Pulsed Nd:YAG laser is used to heat nanoparticles to incandescence temperature and the resulting signal is measured. Mass and energy balance equations are numerically solved to calculate temperature of soot particles in low fluence regime. Assuming Plank black ...

Modeling Time-resolved Interaction Force Mode Afm Imaging

Large Scale Experiments Data Analysis for Estimation of Hydrodynamic Force Coefficients Part 1: Time Domain Analysis

This paper describes various time-domain methods useful for analyzing the experimental data obtained from a circular cylinder force in terms of both wave and current for estimation of the drag and inertia coefficients applicable to the Morison’s equation. An additional approach, weighted least squares method is also introduced. A set of data obtained from experiments on heavily roughened circul...

Cantilevers with integrated sensor for time-resolved force measurement in tapping-mode atomic force microscopy

We present a micromachined cantilever with an integrated high-bandwidth resonator for direct measurement of tip-sample interaction forces in tapping-mode atomic force microscopy. Force measurements are achieved by a diffraction grating that serves as a differential displacement sensor for the tip motion relative to the cantilever body. Time-resolved tip-sample interaction force measurement is d...