Time Course of Classically Conditioned Purkinje Cell Response Is Determined by Initial Part of Conditioned Stimulus
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چکیده
منابع مشابه
Time course of classically conditioned Purkinje cell response is determined by initial part of conditioned stimulus.
Classical conditioning of a motor response such as eyeblink is associated with the development of a pause in cerebellar Purkinje cell firing that is an important driver of the overt response. This conditioned Purkinje cell response is adaptively timed and has a specific temporal profile that probably explains the time course of the overt behavior. It is generally assumed that the temporal prope...
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Pavlovian eyeblink conditioning is a useful experimental model for studying adaptive timing, an important aspect of skilled movements. The conditioned response (CR) is precisely timed to occur just before the onset of the expected unconditioned stimulus (US). The timing can be changed immediately, however, by varying parameters of the conditioned stimulus (CS). It has previously been shown that...
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It is well established that the cerebellum and its associated circuitry are essential for classical conditioning of the eyeblink response and other discrete motor responses (e.g., limb flexion, head turn, etc.) learned with an aversive unconditioned stimulus (US). However, brain mechanisms underlying extinction of these responses are still relatively unclear. Behavioral studies have demonstrate...
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It is well established that the cerebellum and its associated circuitry are essential for classical conditioning of the eyeblink response and other discrete motor responses (e.g., limb flexion, head turn, etc.) learned with an aversive unconditioned stimulus. However, brain mechanisms underlying extinction of these responses are still relatively unclear. Behavioral studies have demonstrated ext...
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Experimental evidence supports the view that the cerebel-lum is involved in the adaptive timing of the classically conditioned eye-blink response. Previous modelling studies have demonstrated that a group of cerebellar Purkinje cells can learn the adaptive timing of the eye-blink response if the cells in the group have predeened response la-tencies which cover the range of conditionable interst...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2011
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.1653-11.2011