Tie2 lineage deletion of 6 integrin: endothelial and haematopoietic cells in neovascularization
نویسندگان
چکیده
منابع مشابه
Tie2-dependent deletion of α6 integrin subunit in mice reduces tumor growth and angiogenesis.
The α6 integrin subunit (α6) has been implicated in cancer cell migration and in the progression of several malignancies, but its role in tumor angiogenesis is unclear. In mice, anti-α6 blocking antibodies reduce tumor angiogenesis, whereas Tie1-dependent α6 gene deletion enhances neovessel formation in melanoma and lung carcinoma. To clarify the discrepancy in these results we used the cre-lox...
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OBJECTIVE Aortic valve disease is a complex process characterized by valve interstitial cell activation, disruption of the extracellular matrix culminating in valve mineralization occurring over many years. We explored the function of the retinoblastoma protein (pRb) in aortic valve disease, given its critical role in mesenchymal cell differentiation including bone development and mineralizatio...
متن کاملExpression of alpha4-integrin defines the earliest precursor of hematopoietic cell lineage diverged from endothelial cells.
Embryonic stem cells can differentiate in vitro into hematopoietic cells through two intermediate stages; the first being FLK1(+) E-cadherin- proximal lateral mesoderm and the second being CD45(-) VE-cadherin+ endothelial cells. To further dissect the CD45(-) VE-cadherin+ cells, we have examined distribution of alpha4-integrin on this cell population, because alpha4-integrin is the molecule exp...
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Embryonic stem cells can differentiate in vitro into hematopoietic cells through two intermediate stages; the first being FLK11 E-cadherin2 proximal lateral mesoderm and the second being CD452 VE-cadherin1 endothelial cells. To further dissect the CD452 VE-cadherin1 cells, we have examined distribution of a4-integrin on this cell population, because a4-integrin is the molecule expressed on hema...
متن کاملp21Cip1 levels differentially regulate turnover of mature endothelial cells, endothelial progenitor cells, and in vivo neovascularization.
p21(Cip1) (p21) controls cell cycle progression and apoptosis in mature endothelial cells (ECs) and regulates size and cycling of the hematopoietic progenitor cell pool. Because circulating endothelial progenitor cells (EPCs) contribute to postnatal neovascularization in addition to mature ECs, we investigated the regulation of ECs and EPCs in p21-deficient mice. Mature aortic EC proliferation ...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2012
ISSN: 0008-6363
DOI: 10.1093/cvr/cvs171