Tidal volume amplitude affects the degree of induced bronchoconstriction in dogs
نویسندگان
چکیده
منابع مشابه
Tidal volume amplitude affects the degree of induced bronchoconstriction in dogs.
When isolated constricted airway smooth muscle is oscillated, muscle tone decreases. We investigated whether changing tidal volume (VT) would affect induced bronchoconstriction in an in vivo canine model. Open-chest dogs were intubated with a double-lumen endotracheal tube, which isolated each main bronchus, and mechanically ventilated with a dual-cylinder ventilator. Bronchial pressure (Pbr) a...
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15 صفحه اولHistamine induced bronchoconstriction and end tidal inspiratory activity in man.
BACKGROUND End tidal inspiratory activity (ETIA) in diaphragm and parasternal intercostal muscles can be evoked in man and in animals by administration of histamine. Exacerbations of asthma and administration of histamine are often accompanied by hyperinflation. The aims of the study were to determine (1) the magnitude of ETIA in response to histamine in man, (2) the relative contributions of c...
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We have assessed the effect of lidocaine (lignocaine) on histamine-induced bronchoconstriction by direct visualization with a superfine fibreoptic bronchoscope. Seven mongrel dogs were anaesthetized with pentobarbital (pentobarbitone) 30 mg kg-1 followed by 2 mg kg-1 h-1 and pancuronium 200 micrograms kg-1 h-1. The trachea was intubated with a tracheal tube containing a second lumen for inserti...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 1999
ISSN: 8750-7587,1522-1601
DOI: 10.1152/jappl.1999.87.5.1674