Ti (WT31)-negative, CD3-positive, large granular lymphocyte leukemia with nonspecific cytotoxicity
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چکیده
منابع مشابه
Ti (WT31)-negative, CD3-positive, large granular lymphocyte leukemia with nonspecific cytotoxicity.
A case of WT31-, CD3+ large granular lymphocyte leukemia is reported. On surface marker analysis, the proliferating cells were found to be CD3+4-8-16+ and WT31-. By two-color immunofluorescence staining, CD3+4-8- cells were found to be WT31-, and a small population of WT31+ cells expressed either CD4 or CD8. WT31-, CD3+ cells were also identified in a bulk culture of lymphocytes expanded in vit...
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Clonal diseases of large granular lymphocytes (LGLs) represent a spectrum of clinically rare lymphoproliferative malignancies arising from either mature T-cell (CD3(+)) or natural killer (NK)-cell (CD3(-)) lineages. The clinical behavior of these disorders ranges from indolent to very aggressive. Patients with symptomatic indolent T-cell or NK-cell LGL leukemia are usually treated with immunosu...
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A clinical entitity of large granular lymphocyte (LGL) leukemia was established based on the observation of clonality and the demonstration of tissue invasion by LGL of marrow, spleen, and liver.' The clonal expansion of LGL can be divided into two major lineages: CD3+ and CD3(natural killer: NK); however, it is still difficult to prove clonality in CD3NK LGL proliferation because CD3cells do n...
متن کاملEpstein-Barr Virus-Associated CD3- Large Granular Lymphocyte Leukemia Presenting With Polycranial Nerve Palsies
A clinical entitity of large granular lymphocyte (LGL) leukemia was established based on the observation of clonality and the demonstration of tissue invasion by LGL of marrow, spleen, and liver.' The clonal expansion of LGL can be divided into two major lineages: CD3+ and CD3(natural killer: NK); however, it is still difficult to prove clonality in CD3NK LGL proliferation because CD3cells do n...
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ژورنال
عنوان ژورنال: Blood
سال: 1988
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v71.4.923.923