THz irradiation inhibits cell division by affecting actin dynamics

Biological phenomena induced by terahertz (THz) irradiation are described in recent reports, but underlying mechanisms, structural and dynamical change of specific molecules still unclear. In this paper, we performed time-lapse morphological analysis human cells found that THz halts cell division at cytokinesis. At the end cytokinesis, contractile ring, which consists filamentous actin (F-actin), needs to disappear; however, it remained for 1 hour under irradiation. Induction functional structures F-actin was also observed interphase cells. Similar were chemical treatment (jasplakinolide), indicating assists polymerization. We previously reported enhances polymerization purified vitro; our current work shows increases cytoplasmic vivo. Thus, identified one key biomechanisms affected waves.