Thyrotoxicosis: relations between clinical state and biochemical changes during carbimazole treatment.

Thyrotoxicosis: relations between clinical state and biochemical changes during carbimazole treatment.

The relation between clinical and biochemical changes in thyrotoxicosis were studied in 12 patients with Graves's disease who were being treated with carbimazole. Clinical assessment (using the Crooks-Wayne index) was combined with the measurement of free thyroxine and triiodothyronine indices (FT4I and FT3I) and the assessment of two tissue markers of thyroid hormone action--sex-hormone-bindin...

Carbimazole--resistant thyrotoxicosis.

Carbimazole (Neo-Mercazole) in Thyrotoxicosis

stressed the freedom from toxicity and potency of carbimazole as an anti-thyroid drug. Though potent, thiourea derivatives had proved to have a significant toxic risk. For this reason, most recent workers have concentrated on a comparison of carbimazole with thiourea drugs in regard to studies of toxicity. McGavack, et al. (1956), in describing their experiences in forty-one cases with special ...

Treatment of thyrotoxicosis resistant to carbimazole with corticosteroids.

We report two patients whose thyrotoxicosis failed to respond to conventional treatment with carbimazole. The patients remained persistently hyperthyroid, both clinically and biochemically, despite several months of carbimazole therapy at the maximum recommended doses. Prednisolone 20 mg per day was then given in addition to the antithyroid drug and a dramatic response observed in both cases. T...

Clinical and biochemical changes during exchange transfusion.

The development of exchange transfusion has greatly altered the prognosis of haemolytic disease of the newborn and the procedure is now accepted as being essential in cases of any severity. It is carried out wherever the criteria for operation are fulfilled and by operators of varying skill and experience. The difficulties associated with blood transfusion have received increasing attention in ...