منابع مشابه
Thrombotic Microangiopathy in Renal Allografts
The term “thrombotic microangiopathy” (TMA) encompasses non-inflammatory small vessel vasculopathies that are caused by severe endothelial and medial smooth muscle cell injury/necrosis. TMAs can be promoted by a variety of “toxic” stimuli ranging from malignant range hypertension, E. coli infections with bloody diarrhea, radiation, systemic diseases such as scleroderma to iatrogenic events such...
متن کاملInflammatory cells in renal allografts.
Renal transplants are injured by a variety of diseases and pathways. One important cause for acute and chronic graft failure is rejection. Since the advent of kidney transplantation, it has become apparent that rejection is a cellular and/or antibody mediated inflammatory process with different histologic phenotypes, and clinical degrees of severity. In recent years, the immunohistochemical det...
متن کاملCyclosporine-associated thrombotic microangiopathy in renal allografts.
BACKGROUND The association between cyclosporine (CsA) and thrombotic microangiopathy (TMA) in renal allografts is well documented. However, predisposing factors and therapy guidelines are not adequately characterized. METHODS We reviewed 188 patients with kidney or kidney-pancreas transplants who were treated between January 1994 and December 1996 with prednisone, CsA, or tacrolimus, and azat...
متن کاملEarly glomerular dysfunction in human renal allografts.
BACKGROUND The long-term outcome of renal allografts is characterized by a progressive deterioration of renal function and graft loss. Our aim was to determine early glomerular functional abnormalities, before they become clinically apparent. METHODS Glomerular hemodynamics and dextran sieving were characterized in 21 well-functioning cadaveric renal allograft recipients [normal glomerular fi...
متن کاملGlomerular basement membrane thickening in renal allografts.
Diffuse thickening of glomerular basement membranes (GBM) was optically observed in the renal grafts of 15 patients (21 specimens) among 70 recipients (128 specimens). Most of these specimens with diffuse GBM thickening were examined ultrastructurally. All cases with the above change were only found in allografts. The correlation was observed between the degree of GBM thickening and the clinica...
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ژورنال
عنوان ژورنال: Clinical Transplantation
سال: 2009
ISSN: 0902-0063,1399-0012
DOI: 10.1111/j.1399-0012.2009.01001.x