منابع مشابه
Primary and secondary thyroid hormone transporters
Thyroid hormones (TH) are essential for the development of the human brain, growth and cellular metabolism. Investigation of TH transporters became one of the emerging fields in thyroid research after the discovery of inactivating mutations in the Monocarboxylate transporter 8 (MCT8), which was found to be highly specific for TH transport. However, additional transmembrane transporters are also...
متن کاملMinireview: Pathophysiological importance of thyroid hormone transporters.
Thyroid hormone metabolism and action are largely intracellular events that require transport of iodothyronines across the plasma membrane. It has been assumed for a long time that this occurs by passive diffusion, but it has become increasingly clear that cellular uptake and efflux of thyroid hormone is mediated by transporter proteins. Recently, several active and specific thyroid hormone tra...
متن کاملThyroid hormone transporters in the human.
Corresponding Authors: Anastasios Papadimitriou, MD, 3 Department of Pediatrics, University of Athens School of Medicine, “Attikon” University Hospital, 1 Rimini Street, 124 64 Athens, Greece, Tel: +30-210-5832046, Fax:+30-210-5832229, e-mail: [email protected] Received 31-08-11, Revised 08-09-11, Accepted 25-09-11
متن کاملRegulation of thyroid hormone-induced development in vivo by thyroid hormone transporters and cytosolic binding proteins.
Differential tissue sensitivity/responsivity to hormones can explain developmental asynchrony among hormone-dependent events despite equivalent exposure of each tissue to circulating hormone levels. A dramatic vertebrate example is during frog metamorphosis, where transformation of the hind limb, brain, intestine, liver, and tail are completely dependent on thyroid hormone (TH) but occurs async...
متن کاملExpression of thyroid hormone transporters in the human hypothalamus.
CONTEXT Transport of thyroid hormone across the plasma membrane is required for proper thyroid hormone action and metabolism. Several specific thyroid hormone transporters have been identified capable of facilitating uptake and/or efflux of thyroid hormones. Monocarboxylate transporter (MCT)-8, MCT10, and organic anion transporting polypeptide 1C1 (OATP1C1) are the best-characterized specific t...
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ژورنال
عنوان ژورنال: Endocrine Reviews
سال: 2019
ISSN: 0163-769X,1945-7189
DOI: 10.1210/endrev/bnz008