منابع مشابه
Thymus Cell Maturation
Outer thymic cortical large lymphocytes were labeled by transcapsular administration of tritiated thymidine. By 2-4 days after labeling, small and medium labeled lymphocyte descendants were found throughout the cortex and in the medulla. The labeled cortical lymphocytes undergo pycnosis after parenteral administration of hydrocortisone 24 h previously, but their (labeled) medullary descendants ...
متن کاملLymphocyte maturation in the human thymus. Relevance of purine nucleotide metabolism for intrathymic T cell function.
The combination of centrifugal elutriation as an efficient and reproducible method to separate thymocytes by size, micromethods to assess purine interconversion enzymes, and assessment of purine (deoxy)nucleoside inhibition of mitogen responses enabled us to study purine metabolism at the intrathymic level. Out of six fractions, four (nos. 3-6), containing medium- and large-sized lymphocytes, s...
متن کاملAppearance and Maturation of T-Cell Subsets During Rat Thymus Ontogeny
In previous papers, we have described the ontogenetical development of thymic stromal-cell components (epithelium, macrophages, dendritic cells) of Wistar rats. Here, we correlate those results with the maturation of rat T-cell precursors along the fetal and postnatal life. First T-cell precursors, which colonize the thymus anlage around days 13-14 of gestation, largely express CD45, CD43, CD53...
متن کاملThymus Cell Migration
THE PRECEDING STUDIES HAVE ESTABLISHED THE FOLLOWING POINTS: Intrathymic labeling of thymic lymphocytes provides an adequate marker system to detect the migration of thymus cells to peripheral lymphoid sites. In the newborn, this comprises a major portion of the total lymphocyte population in lymph nodes and spleen. In the adult, this migration is limited to specific portions of lymph nodes and...
متن کاملAffinity maturation of antibodies requires integrity of the adult thymus.
The generation of B-cell responses to proteins requires a functional thymus to produce CD4(+) T cells which helps in the activation and differentiation of B cells. Because the mature T-cell repertoire has abundant cells with the helper phenotype, one might predict that in mature individuals, the generation of B-cell memory would proceed independently of the thymus. Contrary to that prediction,...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1973
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.137.2.504