Thrombospondin-1 Inhibits TCR-Mediated T Lymphocyte Early Activation
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چکیده
منابع مشابه
Thrombospondin-1 inhibits TCR-mediated T lymphocyte early activation.
Biological activities of the matrix glycoprotein thrombospondin-1 (TSP1) are cell type specific and depend on the relative expression or activation of several TSP1 receptors. Although engaging individual TSP1 receptors in T lymphocytes can elicit costimulating signals, in this study we show that intact TSP1 inhibits TCR-mediated T cell activation, assessed globally using cDNA microarrays. TSP1 ...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2001
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.166.4.2427