Three Novel Collagen VI Chains with High Homology to the α3 Chain
نویسندگان
چکیده
منابع مشابه
Overexpression of collagen VI α3 in gastric cancer
Collagen VI is significant in the progression of numerous types of cancer. Type VI collagen consists of three α-chains and collagen VI α3 (COL6A3) encodes the α3 chain. The overexpression of COL6A3 has been demonstrated to correlate with high-grade ovarian cancer and contributes to cisplatin resistance; however, its role in human gastric cancer (GC) remains unclear. Using microarray meta-analys...
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Pericellular α3(V) collagen can affect the functioning of cells, such as adipocytes and pancreatic β cells. Here we show that α3(V) chains are an abundant product of normal mammary gland basal cells, and that α3(V) ablation in a mouse mammary tumour model inhibits mammary tumour progression by reducing the proliferative potential of tumour cells. These effects are shown to be primarily cell aut...
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Eibl, H. & Lands, W. E. M. (1969) Anal. Blochem. 30,5 1-57 Furthmayr, H. (1978) J. Supramol. Struct. 9,79-95 Grant, C. W. M. & McConnell, H. M. (1974) Proc. Natl. Acad. Sci. U S A . 17,46534657 Hesketh, T. R., Smith, G. A., Houslay, M. D., McGill, K. A., Birdsall, N. N. J., Metcalfe, J. and Warren, G. B. (1976) Biochemistry IS, 4145-415 1 Commun. 68,363-368 Lowry, 0. H., Rosebrough, N. J., Farr...
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In conclusion, we have provided experimental and theoretical evidence that the a-helical, coiledcoil domain of laminin is responsible for chain assembly and chain selectivity. None of the laminin chains appears to be designed for formation of homodimers, although these are common in many other fibrous proteins [ 111. Only selected heteroassociations are stable in laminin isoforms. The data on f...
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Patients suffering from collagen VI related myopathies caused by mutations in COL6A1, COL6A2 and COL6A3 often also display skin abnormalities, like formation of keloids or "cigarette paper" scars, dry skin, striae rubrae and keratosis pilaris (follicular keratosis). Here we evaluated if Col6a1 null mice, an established animal model for the muscle changes in collagen VI related myopathies, are a...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2008
ISSN: 0021-9258
DOI: 10.1074/jbc.m709540200