منابع مشابه
Neurotoxic factors released by stimulated human monocytes and THP-1 cells.
Activated monocytes/macrophages are known to release toxic materials. Identification of these materials is important for developing more effective treatments for inflammatory disorders where self attack occurs. We stimulated human monocytes and THP-1 cells with LPS/IFNγ and measured the toxic effects of their conditioned media against differentiated human NT-2 cells. Their cytotoxicity, as meas...
متن کاملHepcidin Induces M1 Macrophage Polarization in Monocytes or THP-1 Derived Macrophages
Background: Macrophage polarization plays a critical role in determining the inflammatory states. Hepcidin is a key negative regulator of iron homeostasis and functions. Although hepcidin has been shown to affect ferroportin expression in macrophages, whether it affects macrophage polarization is still largely unknown. Objective: To address whether hepcidin ind...
متن کاملVCAM-1-induced inwardly rectifying K(+) current enhances Ca(2+) entry in human THP-1 monocytes.
Hyperpolarization in human leukemia THP-1 monocytes adherent to vascular cell adhesion molecule (VCAM)-1 is due to an induction of inwardly rectifying K(+) currents (I(ir)) (Colden-Stanfield M and Gallin EK, Am J Physiol Cell Physiol 275: C267-C277, 1998). We determined whether the VCAM-1-induced hyperpolarization is sufficient to augment the increase in intracellular free calcium ([Ca(2+)](i))...
متن کاملAmelioration of Glucolipotoxicity-Induced Endoplasmic Reticulum Stress by a “Chemical Chaperone” in Human THP-1 Monocytes
Chronic ER stress is emerging as a trigger that imbalances a number of systemic and arterial-wall factors and promote atherosclerosis. Macrophage apoptosis within advanced atherosclerotic lesions is also known to increase the risk of atherothrombotic disease. We hypothesize that glucolipotoxicity might mediate monocyte activation and apoptosis through ER stress. Therefore, the aims of this stud...
متن کاملVCAM-1-induced inwardly rectifying K current enhances Ca entry in human THP-1 monocytes
Colden-Stanfield, Margaret, and Mary Scanlon. VCAM-1-induced inwardly rectifying K current enhances Ca entry in human THP-1 monocytes. Am J Physiol Cell Physiol 279: C488–C494, 2000.—Hyperpolarization in human leukemia THP-1 monocytes adherent to vascular cell adhesion molecule (VCAM)-1 is due to an induction of inwardly rectifying K currents (Iir) (Colden-Stanfield M and Gallin EK, Am J Physio...
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ژورنال
عنوان ژورنال: Annals of Translational Medicine
سال: 2016
ISSN: 2305-5839,2305-5847
DOI: 10.21037/atm.2016.08.53