منابع مشابه
Thymus-derived Glucocorticoids Regulate Antigen-specific Positive Selection
While it is generally believed that the avidity of the T cell antigen receptor (TCR) for self antigen/major histocompatibility complex (MHC) determines a thymocyte's fate, how the cell discriminates between a stimulus that causes positive selection (survival) and one that causes negative selection (death) is unknown. We have previously demonstrated that glucocorticoids are produced in the thymu...
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O ne of the many mysteries that loomed over the field of immunology in its dark ages (that period prior to characterization of the TCR and peptide binding by MHC molecules) was the process of T cell development and selection of the receptor repertoire in the thymus. The work of Hogquist and colleagues was the culmination of theoretical and experimental work starting decades earlier (1, 2), and ...
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As advances in computational technology have made it possible to apply Bayesian methods to situations that are increasingly complex, using a wider variety of models that are increasingly more sophisticated, problems regarding model choice are now of central importance. As a result, the development of methods for doing model selection is now at the forefront of research in Bayesian statistics. T...
متن کاملBone marrow-derived cells fail to induce positive selection in thymus reaggregation cultures
The requirements for inducing positive selection of T cells were examined in thymus reaggregation cultures, a system in which dispersed populations of immature CD4+8+ cells and purified thymic epithelial cells (TEC) are reaggregated in tissue culture. Studies with TEC from mice selectively lacking major histocompatibility complex (MHC) class I (I-II+), class II (I+II-), or both class I and II (...
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To elucidate the funciton of the mouse TL antigen in the thymus, we have derived two TL transgenic mouse strains by introducing Tl alpha 2-3 of A strain origin with its own promoter onto a C3H background with no expression of TL in the thymus. These transgenic mouse strains, both of which express high levels of Tla2-3-TL antigen in their thymus, were analyzed for their T cell function with emph...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2016
ISSN: 0300-9475
DOI: 10.1111/sji.12415