Thiourethane-functionalized fillers: biological properties and degradation resistance
نویسندگان
چکیده
This study determined the effect of thiourethane-functionalized fillers (TU) on antimicrobial properties, cytotoxicity, degree conversion (DC), water sorption (Wsp) and solubility (Wsl) experimental composites. TU-modified were added at different ratios in composites: 0 (Control-TU0), 25% (TU25), 50% (TU50), 75% (TU75) 100wt% (TU100). The properties detected through exhaustion test counting Streptococus mutans colonies for biofilm formation. Cytotoxicity to human gingival fibroblasts was evaluated three parameters: XTT (2,3-Bis-(2-Methoxy-4-Nitro-5-Sulfophenyl)-2H-Tetrazolium-5-Carboxanilide), NRU (Neutral Red Uptake assay) CVDE (Crystal Violet Dye Exclusion test)) same cells. ELISA used measure IL-6 b-FGF biomarkers. DC by Fourier-transformed infrared spectroscopy, while Wsp Wsl mass variations. Inhibitory capacity formation not observed any material. All groups presented least 70% cell survival within periods (24h 7 days). Positive control (toxic) had high values low values. No significant variations DC, Wsp, among groups. use thiourethane did present cytotoxic activity tested materials equivalent those conventionally dentistry.
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ژورنال
عنوان ژورنال: Brazilian Oral Research
سال: 2021
ISSN: ['1806-8324', '1807-3107']
DOI: https://doi.org/10.1590/1807-3107bor-2021.vol35.0018