Thiopurine Methyltransferase Genotype and the Toxicity of Azathioprine in Japanese.
نویسندگان
چکیده
منابع مشابه
Thiopurine methyltransferase genotype and the toxicity of azathioprine in Japanese.
OBJECTIVE Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that preferentially catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including Azathioprine (AZA). It has been reported that the level of AZA toxicity is dependent on the TPMT genotypes in Caucasian individuals; we thus investigated this relationship in Japanese. METHODS The TPMT genotype was d...
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ژورنال
عنوان ژورنال: Internal Medicine
سال: 1999
ISSN: 0918-2918,1349-7235
DOI: 10.2169/internalmedicine.38.944