منابع مشابه
Highlight: dynamics of thiol-based redox switches.
Four years ago the German Society for Biochemistry and Molecular Biology (GBM) established a study group dedicated to ‘Redox Biology’. Members of this group subsequently launched a research network on ‘Dynamics of Thiol-based Redox Switches in Cellular Physiology’, now funded by the German Research Council (DFG) as a priority program (for further information see: www.thiolswitches.de). Within t...
متن کاملThiol-based redox switches in prokaryotes.
Bacteria encounter reactive oxygen species (ROS) as a consequence of the aerobic life or as an oxidative burst of activated neutrophils during infections. In addition, bacteria are exposed to other redox-active compounds, including hypochloric acid (HOCl) and reactive electrophilic species (RES) such as quinones and aldehydes. These reactive species often target the thiol groups of cysteines in...
متن کاملThiol-based redox switches in eukaryotic proteins.
For many years, oxidative thiol modifications in cytosolic proteins were largely disregarded as in vitro artifacts, and considered unlikely to play significant roles within the reducing environment of the cell. Recent developments in in vivo thiol trapping technology combined with mass spectrometric analysis have now provided convincing evidence that thiol-based redox switches are used as molec...
متن کاملThiol-based redox switches and gene regulation.
Cysteine is notable among the universal, proteinogenic amino acids for its facile redox chemistry. Cysteine thiolates are readily modified by reactive oxygen species (ROS), reactive electrophilic species (RES), and reactive nitrogen species (RNS). Although thiol switches are commonly triggered by disulfide bond formation, they can also be controlled by S-thiolation, S-alkylation, or modificatio...
متن کاملThiol-based regulatory switches.
Thiol-based regulatory switches play central roles in cellular responses to oxidative stress, nitrosative stress, and changes in the overall thiol-disulfide redox balance. Protein sulfhydryls offer a great deal of flexibility in the different types of modification they can undergo and the range of chemical signals they can perceive. For example, recent work on OhrR and OxyR has clearly establis...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
سال: 2014
ISSN: 1570-9639
DOI: 10.1016/j.bbapap.2014.03.007