Thiazolidinediones Inhibit Lipoprotein Lipase Activity in Adipocytes
نویسندگان
چکیده
منابع مشابه
The reciprocal regulation of lipoprotein lipase activity and hormone-sensitive lipase activity in rat adipocytes.
The regulation of lipoprotein lipase activity was studied in rat adipocytes. Incubation of fat cells for 60 mm in buffer without glucose and insulin resulted in a 50% decrease in lipoprotein lipase activity. This decrease was prevented by glucose and insulin. Inhibition of fat cell protein synthesis by cycloheximide abolished the effect of glucose and insulin and caused a rapid decay of lipopro...
متن کاملThe lipoprotein lipase (clearing-factor lipase) activity of bovine subcutaneous adipose tissue and isolated adipocytes [proceedings].
Kane, J. P., Sata, T., Hamilton, R. L. & Havel, R. J . (1975) J. Clin. I n i ~ s t . 56, 1622-1634 Langer, T., Strober, W. &Levy, R. 1. (1972)J. Clin. Invest. 51, 1528-1536 Lowry, 0 . H., Rosebrough, N. J., Farr, A. L. & Randall, R . J. ( I 95 I ) J . Bid. Cham. 193,265-275 Matthews, C. M. E. (1957) Phys. Med. B i d . 2, 36-53 Miller, G. J. & Miller, N. E. (1975) Lancer i , 16-19 Packard, C. J....
متن کاملASP enhances in situ lipoprotein lipase activity by increasing fatty acid trapping in adipocytes.
Acylation-stimulating protein (ASP) increases triglyceride (TG) storage (fatty acid trapping) in adipose tissue and plays an important role in postprandial TG clearance. We examined the capacity of ASP and insulin to stimulate the activity of lipoprotein lipase (LPL) and the trapping of LPL-derived nonesterified fatty acid (NEFA) in 3T3-L1 adipocytes. Although insulin increased total LPL activi...
متن کاملEffect of scopoletin on lipoprotein lipase activity in 3T3-L1 adipocytes.
Hypertriglyceridemia is an independent risk factor of cardiovascular diseases. It is caused by the imbalance between hepatic triglyceride production and peripheral removal. Lipoprotein lipase (LPL) plays a central role in the removal of plasma triglyceride. During the screening of possible anti-dyslipidemic drugs, we observed that scopoletin (6-methoxy-7-hydroxycoumarin) significantly increased...
متن کاملMechanisms of decreased lipoprotein lipase activity in adipocytes of starved rats depend on duration of starvation.
The aim of this study was to delineate the mechanisms by which varying periods of starvation decrease lipoprotein lipase (LPL) activity in rat adipose tissue. LPL mRNA levels and rates of LPL synthesis, degradation and secretion were compared in adipocytes from male rats that had been fed or starved for 1 or 3 d. The decreased LPL activity after 3 d of starvation (-76%) was explained mainly by ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1998
ISSN: 0021-9258
DOI: 10.1074/jbc.273.40.26117