Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors

Synthesis and biological assessment of 2-hydroxyiminoethanones as anti-inflammatory and β-amyloid aggregation inhibitors

Alzheimer’s disease (AD) is a neuroinflammatory based pathologic state in which β-amyloid aggregates are a major devastating agents. In this study, a series of 2-hydroxyiminoethanones were synthesized and evaluated as anti-inflammatory in carrageenan and formalin tests and inhibitors of β-amyloid aggregation. Compounds 1-10b were synthesized through a two-step reaction. Results: Compounds 1-5b ...

Synthesis and biological assessment of 2-hydroxyiminoethanones as anti-inflammatory and β-amyloid aggregation inhibitors

Alzheimer’s disease (AD) is a neuroinflammatory based pathologic state in which β-amyloid aggregates are a major devastating agents. In this study, a series of 2-hydroxyiminoethanones were synthesized and evaluated as anti-inflammatory in carrageenan and formalin tests and inhibitors of β-amyloid aggregation. Compounds 1-10b were synthesized through a two-step reaction. Results: Compounds 1-5b ...

Thermodynamic and Structural Analysis of Protein Aggregation and Amyloid Formation

Short Peptides as Inhibitors of Amyloid Aggregation

The misfolding and aggregation of proteins into amyloid has been linked to a variety of age-related diseases. Aggregation of proteins, such as Aβ in Alzheimer's disease and Islet Amyloid Polypeptide (IAPP, amylin) in type 2 diabetes, appears to lead to the formation of toxic assemblies. These assemblies range in size from small oligomers (2-8 proteins) to large fibrils (thousands of proteins). ...

Kinetic and Thermodynamic Constraints for the Structural Design of Glycolysis

REINHART HEINRICH, §, FRANCISCO MONTERO, ¶, EDDA KLIPP, §, THOMAS G. WADDELL,~ and ENRIQUE MELI~NDEZ-HEVIAt § Humboldt-Universitat zu Berlin, Institut for Biologie, Theoretische Biophysik, D-I 0115 Berlin, Germany ¶ Universidad Complutense de Madrid, Departamento de Bioquimica, 28040 Madrid, Spain ~:University of Tennessee, Department of Chemistry, Chattanooga, TN, USA. tUmversidad de la Laguna...