Thermal nociception using a modified Hargreaves method in primates and humans
نویسندگان
چکیده
منابع مشابه
Operant nociception in nonhuman primates.
The effective management of pain is a longstanding public health concern. Morphine-like opioids have long been front-line analgesics, but produce undesirable side effects that can limit their application. Slow progress in the introduction of novel improved medications for pain management over the last 5 decades has prompted a call for innovative translational research, including new preclinical...
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We describe a method for measuring nociception in cattle using a CO(2) laser aimed at the caudal aspect of the metatarsi. In Experiment 1, infrared thermography showed that calves responded by lifting their legs when skin temperatures reached 45-55 degrees C. In Experiment 2a, the validity of the method was tested by comparing the response latencies of 14 calves to two power settings (2.25 W vs...
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Painful sensations can be evoked by application of thermal, mechanical, and chemical stimuli to the blood vessels. The cortical substrates of these sensations are unknown. We therefore used whole-head magnetoencephalography to record cortical responses to painful laser stimuli applied cutaneously and intravenously to the dorsum of the hand in healthy human subjects. Similar to the cutaneous sti...
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ژورنال
عنوان ژورنال: Functional Neurology
سال: 2015
ISSN: 0393-5264
DOI: 10.11138/fneur/2015.30.4.229