Therapeutic Targeting of Regulated Signaling Pathways of Non-Small Cell Lung Carcinoma

Non-small cell lung carcinoma (NSCLC) is the most common cancer globally. Phytochemicals and small molecule inhibitors significantly prevent varying types of cancers, including NSCLC. These therapeutic molecules serve as important sources for new drugs that interfere with cellular proliferation, apoptosis, metastasis, angiogenesis by regulating signaling pathways. affect several cascades, p53, NF-κB, STAT3, RAS, MAPK/ERK, Wnt, AKT/PI3K, are thus implicated in management cancers. This review aims to describe bioactive compounds small-molecule inhibitors, their anticancer action, targeting cascades We highlighted potential Epigallocatechin gallate (EGCG), Perifosine, ABT-737, Thymoquinine, Quercetin, Venetoclax, Gefitinib, Genistein. further offers deeper mechanistic insights into different pathways could be targeted NSCLC therapy phytochemicals inhibitors.