Therapeutic efficacy of favipiravir against Bourbon virus in mice
نویسندگان
چکیده
منابع مشابه
Antiviral efficacy of favipiravir against Ebola virus: A translational study in cynomolgus macaques
BACKGROUND Despite repeated outbreaks, in particular the devastating 2014-2016 epidemic, there is no effective treatment validated for patients with Ebola virus disease (EVD). Among the drug candidates is the broad-spectrum polymerase inhibitor favipiravir, which showed a good tolerance profile in patients with EVD (JIKI trial) but did not demonstrate a strong antiviral efficacy. In order to ga...
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The polymerase inhibitor favipiravir is a candidate for the treatment of Ebola virus disease. Here, we designed a mathematical model to characterize the viral dynamics in 20 mice experimentally infected with Ebola virus, which were either left untreated or treated with favipiravir at 6 or 8days post infection. This approach provided estimates of kinetic parameters of Ebola virus reproduction, s...
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BACKGROUND Pandemic influenza poses a serious threat to global health and the world economy. While vaccines are currently under development, passive immunization could offer an alternative strategy to prevent and treat influenza virus infection. Attempts to develop monoclonal antibodies (mAbs) have been made. However, passive immunization based on mAbs may require a cocktail of mAbs with broade...
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Background and Aim: Hepatitis B virus (HBV) is an important infectious agent in denti-stry necessitating the use of disinfectants to prevent its transmission. This study compared the efficacy of 2/100 sodium hypochlorite disinfectants prepared from 5% solution manufactured by four different manufacturers namely Ashimashi, Paknaz, Vitex and Active for disinfection of surfaces infected with HBV. ...
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The therapeutic efficacy of polyriboinosinic-polyribocytidylic acid stabilized with poly-L-lysine and carboxymethyl cellulose [poly(ICLC)] given alone or in combination with ribavirin was evaluated in Swiss Webster mice infected with Rift Valley fever virus. Four or more 20-micrograms doses of poly(ICLC) given at various intervals beginning 24 h after infection protected all mice against death....
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ژورنال
عنوان ژورنال: PLOS Pathogens
سال: 2019
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1007790