Therapeutic drug monitoring principles in the neonate
نویسندگان
چکیده
منابع مشابه
Drug monitoring in the neonate.
Drug monitoring has recently been extended into the neonatal population largely owing to improvements in analytical techniques. This important area of study represents a wide diversity of patients,-from mature infants to low-birth weight infants owing either to premature birth or intrauterine growth retardation. Neonates provide a highly variable population base which undergoes rapid changes in...
متن کاملTherapeutic drug monitoring--the appropriate use of drug level measurement in the care of the neonate.
Neonates and young infants are in a unique and dynamic pharmacokinetic state, in which they undergo relatively rapid maturational changes in drug absorption, distribution, metabolism, and excretion. In addition to these maturational changes, most drug pharmacokinetic studies in neonates show wide interindividual variability despite similar gestational and postnatal ages. Therapeutic drug monito...
متن کاملTherapeutic Drug Monitoring of Meropenem in Neonate with Necrotizing Enterocolitis: A Challenge
Necrotizing enterocolitis (NEC) continues to be a major cause of neonatal morbidity and mortality. We describe the added value of therapeutic drug monitoring by presenting the case of a preterm infant with severe NEC treated with meropenem. Dosing strategy will achieve adequate patient outcome when treating pathogens with elevated MIC. As safe as meropenem is, there are not enough data for 40 m...
متن کاملA Review on Therapeutic Drug Monitoring of Immunosuppressant Drugs
Immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. This variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. Drug monitoring is widely practiced ...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 1997
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/43.1.222