Theranostics based on microbubbles and ultrasound
نویسندگان
چکیده
منابع مشابه
Ultrasound microbubbles for molecular diagnosis, therapy, and theranostics.
Ultrasound imaging is clinically established for routine screening examinations of breast, abdomen, neck, and other soft tissues, as well as for therapy monitoring. Microbubbles as vascular contrast agents improve the detection and characterization of cancerous lesions, inflammatory processes, and cardiovascular pathologies. Taking advantage of the excellent sensitivity and specificity of ultra...
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Compared with other diagnostic methods, ultrasound is proven to be a safe, simple, non-invasive and cost-effective imaging technique, but the resolution is not comparable to that of magnetic resonance imaging (MRI). Contrast-enhanced ultrasound employing microbubbles can gain a better resolution and is now widely used to diagnose a number of diseases in the clinic. For the last decade, microbub...
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Microbubbles have proven to be useful as diagnostic agents for ultrasound[1,2]. However, they have the potential for a far wider range of uses, both in unmodified form (thus minimising regulatory barriers) and in new forms[3]. These future uses may be divided into diagnostic and therapeutic categories. Routine diagnostic uses of microbubbles relevant to oncology are mainly in the liver, where t...
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Conventional ultrasound has well known short comings in the detection and characterisation of focal liver lesions. A false negative rate of up to 30% has been quoted in the detection of liver metastases and its accuracy in the characterisation of focal liver lesions is poor compared to computed tomography (CT) and magnetic resonance (MR). Ultrasound microbubble contrast agents have redressed th...
متن کاملBlood Brain Barrier Disruption by Focused Ultrasound and Microbubbles: A Numerical Study on Mechanical Effects
Introduction: Microbubbles are widely used as contrast agent in diagnostic ultrasound. Recently they have shown good potential for applications in the therapeutic field such as drug delivery to the brain. Recent studies have shown focused ultrasound in conjunction with injected micro-bubbles could temporarily disrupt blood-brain barrier and let therapeutic agents transport into...
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ژورنال
عنوان ژورنال: Drug Delivery System
سال: 2018
ISSN: 0913-5006,1881-2732
DOI: 10.2745/dds.33.190