Theophylline and Melanocyte-Stimulating Hormone: Effects on Uveal Melanocytes of Adult Rhesus Eyes
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چکیده
منابع مشابه
Effect of melanocyte stimulating hormone on human cultured choroidal melanocytes, uveal melanoma cells, and retinal epithelial cells.
PURPOSE To establish methodology for the culture of human choroidal melanocytes to compare their responsiveness to melanocyte stimulating hormone (MSH) with that of their transformed melanoma counterparts and with that of the retinal epithelial cell. METHODS Choroidal melanocytes from the choroid of eyes enucleated for the presence of malignant melanoma were cultured in MCDB 153 medium supple...
متن کاملY2-Melanocyte-Stimulating Hormone
Peptides of the pro-opiocortin class produce pronounced cardiovascular and natriuretic actions. We have investigated the acute cardiovascular effects of one of the most potent members of this class, y2-melanocyte stimulating hormone (y2-MSH), in rats. Pressor actions of y2MSH administered systemicaMy were eliminated by ganglionic blockade with chlorisondamine. Peripheral cholinergic blockade fa...
متن کاملStimulation of dendritogenesis in the epidermal melanocytes of newborn mice by melanocyte-stimulating hormone.
The number of dendrites and the total length of dendrites in the epidermal melanocytes positive for the dopa reaction were shown to increase when newborn mice were injected with alpha-MSH or DBc-AMP. Moreover, both indices of the degree of dendritogenesis increased when skin explants of newborn mice were cultured in medium containing alpha-MSH or DBc-AMP. Electron-microscopic observation showed...
متن کاملDesacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance
OBJECTIVE Regulation of energy balance depends on pro-opiomelanocortin (POMC)-derived peptides and melanocortin-4 receptor (MC4R). Alpha-melanocyte stimulating hormone (α-MSH) is the predicted natural POMC-derived peptide that regulates energy balance. Desacetyl-α-MSH, the precursor for α-MSH, is present in brain and blood. Desacetyl-α-MSH is considered to be unimportant for regulating energy b...
متن کاملAlpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes.
Epidermal melanocytes are skin cells specialized in melanin production. Activation of the melanocortin 1 receptor (MC1R) on melanocytes by α-melanocyte-stimulating hormone (α-MSH) induces synthesis of the brown/black pigment eumelanin that confers photoprotection from solar UV radiation (UVR). Contrary to keratinocytes, melanocytes are slow proliferating cells that persist in the skin for decad...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1983
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12542961