TheDrosophilatype II receptor, Wishful thinking, binds BMP and myoglianin to activate multiple TGFβ family signaling pathways
نویسندگان
چکیده
منابع مشابه
The Drosophila BMP Type II Receptor Wishful Thinking Regulates Neuromuscular Synapse Morphology and Function
Proper synaptic development is critical for establishing all aspects of neural function including learning, memory, and locomotion. Here, we describe the phenotypic consequences of mutations in the wishful thinking (wit) gene, the Drosophila homolog of the vertebrate BMP type II receptor. Mutations in wit result in pharate lethality that can be rescued by expression of a wit transgene in motor ...
متن کاملwishful thinking Encodes a BMP Type II Receptor that Regulates Synaptic Growth in Drosophila
We conducted a large-scale screen for Drosophila mutants that have structural abnormalities of the larval neuromuscular junction (NMJ). We recovered mutations in wishful thinking (wit), a gene that positively regulates synaptic growth. wit encodes a BMP type II receptor. In wit mutant larvae, the size of the NMJs is greatly reduced relative to the size of the muscles. wit NMJs have reduced evok...
متن کاملInteraction of TGFβ and BMP Signaling Pathways during Chondrogenesis
TGFβ and BMP signaling pathways exhibit antagonistic activities during the development of many tissues. Although the crosstalk between BMP and TGFβ signaling pathways is well established in bone development, the relationship between these two pathways is less well defined during cartilage development and postnatal homeostasis. We generated hypomorphic mouse models of cartilage-specific loss of ...
متن کاملRetrograde Gbb signaling through the Bmp type 2 receptor wishful thinking regulates systemic FMRFa expression in Drosophila.
Amidated neuropeptides of the FMRFamide class regulate numerous physiological processes including synaptic efficacy at the Drosophila neuromuscular junction (NMJ). We demonstrate here that mutations in wishful thinking (wit) a gene encoding a Drosophila Bmp type 2 receptor that is required for proper neurotransmitter release at the neuromuscular junction, also eliminates expression of FMRFa in ...
متن کاملWishful Thinking
and we will write to you when there is a bed available yes I know it's painful, and six months is a long time to wait, but I am afraid we have already lost two wards this year because of the cuts. Mrs Thatcher keeps taking money away from us to spend on Trident Missiles Yes I wish you would write to your Member of Parliament about it. Hello Sister, is it tea time yet? Sister: Not yet I'm afraid...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2005
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2005.06.088