The X-ray Crystal Structure of Human γS-crystallin C-terminal Domain
نویسندگان
چکیده
منابع مشابه
In vitro evolution of an HIV integrase binding protein from a library of C-terminal domain γS-crystallin variants.
A protein without natural binding functions was engineered to bind HIV-1 integrase. Phage display selections applied a library of variants based on the C-terminal domain of the eye lens protein human γS-crystallin. Multiple loop regions were altered to encode libraries with ≈3.6 × 10(11) different variants. A crystallin variant, termed integrase binding protein-10 (IBP-10), inhibits integrase c...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2002
ISSN: 0021-9258
DOI: 10.1074/jbc.m110083200