The weaver mouse: a most cantankerous rodent.
نویسندگان
چکیده
منابع مشابه
Cerebellar Alterations in the Weaver Mouse
The fine structure of the cerebellum of weaver mouse was examined and the paucity of granule cells and their axons, the parallel fibers, was confirmed. Unexpectedly, however, the dendritic spines of the Purkinje cells which, in normal animals, are the postsynaptic mates of the parallel fibers, were present. Furthermore, their essential morphology and their staining reactions were indistinguisha...
متن کاملMembrane specializations of dentritic spines and glia in the weaver mouse cerebellum: a freeze-fracture study
Electron microscopy of thin-sectioned and freeze-fractured preparations of the cerebellum of the weaver mouse indicates that the dendritic spines are morphologically identical to those of their normal littermates. The weaver dendritic spines have been characterized as "unattached" since the synaptic input from the parallel fibers is absent (8-10). The entire region around the dendritic spines i...
متن کاملDevelopment and death of external granular layer cells in the weaver mouse cerebellum: a quantitative study.
Previous studies have identified the cerebellar granule cell as a primary site of gene action in the weaver mutant mouse. The temporal expression of the weaver mutant granule cell phenotype has not been fully investigated. To identify early postnatal expression of the weaver mutant phenotype, we quantitated 4 parameters of cerebellar development in postnatal day 0, 2, 4, 6, and 8 +/+, wv/+, and...
متن کاملA girl with the Weaver syndrome.
A female with the Weaver syndrome is reported. In addition to the characteristic manifestations of overgrowth and advanced bone age, the facies were typical, with a broad forehead, hypertelorism, a long philtrum, micrognathia, and large ears. Like most other patients with Weaver syndrome, she was developmentally delayed, hypertonic, and had a hoarse voice. Other clinical features included promi...
متن کاملIdentification of the weaver Mouse Mutation: The End of the Beginning
region of the GIRK2 protein. Identification of this mutation now provides a clear focus for determining the basis of the phenotypic sequelae that define the wv mouse. GIRK2 is part of a family of inwardly rectifying K ϩ Hershey, Pennsylvania 17033 channels that are activated by G protein subunits (Wick-man et al., 1994; Kofuji et al., 1995). These channels are Neurological mouse mutants have be...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1996
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.93.20.10541