The Use of Fecal Calprotectin Testing in Paediatric Disorders: A Position Paper of the European Society for Paediatric Gastroenterology and Nutrition Gastroenterology Committee

Objectives: The aim of the study was to review evidence regarding clinical use and value fecal calprotectin (FC) measurements in different gastrointestinal disorders children. Methods: A literature search conducted PubMed, MEDLINE, EMBASE, Cochrane databases until October 31, 2019. Subtopics were identified each assigned individual authors. Results: total 28 recommendations voted on using nominal voting technique. Recommendations are given related sampling, measurement methods, results interpretation. 14 authors anonymously recommendation a 9-point scale (1 strongly disagree 9 fully agree). Consensus considered achieved if at least 75% 6, 7, 8, or 9. Conclusions: reached for all recommendations. Limitations FC practice include variability extraction methodology, performance test kits as well need establish local reference ranges because influence factors, such age, diet, microbiota, drugs. main utility present is diagnosis monitoring inflammatory bowel disease (IBD) differentiate it from functional (FAPDs). FC, however, has neither infantile colic nor between organic constipation. rise concentration, may alert risk developing necrotizing enterocolitis help identifying involvement children with Henoch-Schönlein purpura. little Cow's Milk Protein Allergy, coeliac (CD), cystic fibrosis. does distinguish bacterial viral acute gastroenteritis (AGE), diagnose Helicobacter Pylori infection, small intestinal overgrowth (SIBO), appendicitis (AA), polyps.