The Uroprotective Efficacy of Total Ginsenosides in Chinese Ginseng on Chemotherapy with Cyclophosphamide

Hemorrhagic cystitis is a recognizable complication of cyclophosphamide (CYP) attributable to its lively metabolite acrolein, which produces urothelial injury. The study intended examine the uroprotective efficacy total ginsenosides in Chinese ginseng (TGCG) CYP-induced hemorrhagic cystitis. In total, 24 virgin female rats were randomized into four groups as follows: group 1 (control group; injected with normal saline), 2 (injected CYP plus placebo 3 (given and TGCG (200 mg/kg)), 4 2-mercaptoethane sulfonate sodium (Mesna, 30 mg/kg)). An evaluation by cystometry was conducted. Values voiding interval assessed anesthetized histological examinations bladders measured. analysis, significantly reduced group. Mesna increased values, individually. Bladder edema injury examined after contact CYP. Contrasted given CYP, cystitis, thickness, scores mucosal break submucosal bladder. conclusion, these findings mean that treatment can avoid decreases may participate chief character uroprotection