The UCHL1 S18Y polymorphism and Parkinson’s disease in a Japanese population
نویسندگان
چکیده
منابع مشابه
UCHL1 S18Y variant is a risk factor for Parkinson’s disease in Japan
BACKGROUND A recent meta-analysis on the UCHL1 S18Y variant and Parkinson's disease (PD) showed a significant inverse association between the Y allele and PD; the individual studies included in that meta-analysis, however, have produced conflicting results. We examined the relationship between UCHL1 S18Y single nucleotide polymorphism (SNP) and sporadic PD in Japan. METHODS Included were 229 ...
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The ubiquitin carboxyl-terminal esterase L1 gene, UCHL1, located on chromosome 4p14, has been studied as a potential candidate gene for Parkinson's disease risk. The authors conducted a Human Genome Epidemiology review and meta-analysis of published case-control studies of the UCHL1 S18Y variant and Parkinson's disease in Asian and Caucasian samples. The meta-analysis of studies in populations ...
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ژورنال
عنوان ژورنال: Parkinsonism & Related Disorders
سال: 2011
ISSN: 1353-8020
DOI: 10.1016/j.parkreldis.2011.01.019