The Tumor Suppressor Par-4 Activates an Extrinsic Pathway for Apoptosis
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چکیده
منابع مشابه
The Tumor Suppressor Par-4 Activates an Extrinsic Pathway for Apoptosis
Prostate apoptosis response-4 (Par-4) is a proapoptotic protein with intracellular functions in the cytoplasm and nucleus. Unexpectedly, we noted Par-4 protein is spontaneously secreted by normal and cancer cells in culture, and by Par-4 transgenic mice that are resistant to spontaneous tumors. Short exposure to endoplasmic reticulum (ER) stress-inducing agents further increased cellular secret...
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*Institute of Genetics, University of Bonn, D-53117 Bonn, Germany ‡present address: Institute of Pharmacology and Toxicology, University Hospital of Johann Wolfgang Goethe-University of Frankfurt am Main, D-60590 Frankfurt am Main, Germany §present address: Institute of Health Sciences, Sargent College, Boston University, Boston, MA 02215, USA ||Institute of Structural Biology (IBI-2), Research...
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ژورنال
عنوان ژورنال: Cell
سال: 2009
ISSN: 0092-8674
DOI: 10.1016/j.cell.2009.05.022