The transporter associated with antigen processing TAP: structure and function
نویسندگان
چکیده
منابع مشابه
Specific lipids modulate the transporter associated with antigen processing (TAP).
The transporter associated with antigen processing (TAP) plays a key role in adaptive immunity by translocating proteasomal degradation products from the cytosol into the endoplasmic reticulum lumen for subsequent loading onto major histocompatibility (MHC) class I molecules. For functional and structural analysis of this ATP-binding cassette complex, we established the overexpression of TAP in...
متن کاملThe transporter associated with antigen processing (TAP): structural integrity, expression, function, and its clinical relevance.
BACKGROUND The transporter associated with antigen processing (TAP), a member of the family of ABC transporters, plays a crucial role in the processing and presentation of the major histocompatibility complex (MHC) class I restricted antigens. TAP transports peptides from the cytosol into the endoplasmic reticulum, thereby selecting peptides matching in length and sequence to respective MHC cla...
متن کاملVaricellovirus UL49.5 Proteins Differentially Affect the Function of the Transporter Associated with Antigen Processing, TAP
Cytotoxic T-lymphocytes play an important role in the protection against viral infections, which they detect through the recognition of virus-derived peptides, presented in the context of MHC class I molecules at the surface of the infected cell. The transporter associated with antigen processing (TAP) plays an essential role in MHC class I-restricted antigen presentation, as TAP imports peptid...
متن کاملDistinct functions and cooperative interaction of the subunits of the transporter associated with antigen processing (TAP).
The ATP-binding cassette (ABC) transporter TAP translocates peptides from the cytosol to awaiting MHC class I molecules in the endoplasmic reticulum. TAP is made up of the TAP1 and TAP2 polypeptides, which each possess a nucleotide binding domain (NBD). However, the role of ATP in peptide binding and translocation is poorly understood. We present biochemical and functional evidence that the NBD...
متن کاملFunctional non-equivalence of ABC signature motifs in the transporter associated with antigen processing (TAP)
The abbreviations used are: ABC, ATP-binding cassette; CFTR, cystic fibrosis transmembrane conductance regulator; ER, endoplasmic reticulum; IP, immunoprecipitation; MHC, major histocompatibility complex; NBD, nucleotide-binding domain; PBS, phosphatebuffered saline; PCR, polymerase chain reaction; P-gp, P-glycoprotein; TAP, transporter associated with antigen processing; TMD, transmembrane dom...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Letters
سال: 1999
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(99)01676-2