The TP53 codon 72 polymorphism and predisposition to adrenocortical cancer in Polish patients
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چکیده
منابع مشابه
The TP53 codon 72 polymorphism and predisposition to adrenocortical cancer in Polish patients.
The TP53 polymorphism occurs at codon 72 of exon 4 with two alleles encoding either arginine or proline. The association between this common polymorphism and risk of different cancers has been extensive studied, however various reports are controversial. We have analyzed the 72Pro polymorphic variant in patients with adrenocortical tumors to evaluate whether 72G--> C substitution at codon 72 of...
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The amino acid substitution Arg72Pro in the TP53 protein has an impact on the biochemical and biological activity of this protein, and is associated with several types of cancers. However, the Arg72Pro polymorphism exhibits inconsistent contribution as a risk factor in various cancer types. Therefore, using PCR-RFLPs, we investigated the distribution of Arg72Pro genotypes and alleles in patient...
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ژورنال
عنوان ژورنال: Oncology Reports
سال: 2006
ISSN: 1021-335X,1791-2431
DOI: 10.3892/or.16.1.65