منابع مشابه
Timed Patterns: TCOZ to Timed Automata
The integrated logic-based modeling language, Timed Communicating Object Z (TCOZ), is well suited for presenting complete and coherent requirement models for complex real-time systems. However, the challenge is how to verify the TCOZ models with tool support, especially for analyzing timing properties. Specialized graph-based modeling technique, Timed Automata (TA), has powerful mechanisms for ...
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15 صفحه اولRegulation of iron homeostasis by the p53-ISCU pathway
Accumulation of iron in tissues increases the risk of cancer, but iron regulatory mechanisms in cancer tissues are largely unknown. Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis. p53 activation induced ISCU expression t...
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ژورنال
عنوان ژورنال: Immunity
سال: 2019
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2019.04.012