The therapeutic efficacy of curcumin nanoemulsion versus Spiramycin in Toxoplasma gondii (ME49 strain) chronically infected mice
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چکیده
منابع مشابه
Toxoplasma gondii Actively Inhibits Neuronal Function in Chronically Infected Mice
Upon infection with the obligate intracellular parasite Toxoplasma gondii, fast replicating tachyzoites infect a broad spectrum of host cells including neurons. Under the pressure of the immune response, tachyzoites convert into slow-replicating bradyzoites, which persist as cysts in neurons. Currently, it is unclear whether T. gondii alters the functional activity of neurons, which may contrib...
متن کاملEarly recognized antigen (p34) of Toxoplasma gondii after peroral ingestion of tissue cyst forming strain (Me49 strain) in mice.
Serum from mouse orally ingested with tissue cyst forming strain (Me49) of Toxoplasma gondii was assayed by Western blot and immunofluorescene assay (IFA) to establish early responses in antigenicity of the parasite in mouse model of foodborne toxoplasmosis. Sera were collected weekly to blot the RH antigen transferred onto nitrocellulose paper after being separated by 12% SDS-PAGE. With the se...
متن کاملAnterior uveitis in a kitten infected with Toxoplasma gondii (Tehran strain)
Ocular lesions are a common manifestation of toxoplasmosis in cats. In this survey, 10 healthy Syrianmice were infected through intraperitoneal inoculation of bradyzoites of Toxoplasma gondii (Tehran strain).Mice were killed 30 days after inoculation and the suspension of their brains was prepared, after confirmationof the infection. Seven kittens were fed with the infected mice brain suspensio...
متن کاملIdentification of potential apicoplast associated therapeutic targets in human and animal pathogen Toxoplasma gondii ME49
UNLABELLED Toxoplasma gondii ME49 is an obligatory intracellular apicomplexa parasite that causes toxoplasmosis in humans, domesticated and wild animals. Waterborne outbreaks of acute toxoplasmosis worldwide reinforce the transmission of Toxoplasma gondii ME49 to humans through contaminated water and may have a greater epidemiological impact than previously believed. In the quest for drug and v...
متن کاملEfficacy of Black Seed Oil from Nigella sativa against Murine Infection with Cysts of Me49 Strain of Toxoplasma gondii
Background: New therapies for toxoplasmosis are critically needed. Nigella sativa, commonly known as black seed or black cumin, has been known to include many medicinal properties. It has anti-inflammatory, and immuno-potentiating effects, antihelminthic and antiprotozoal activities. Objective: To study the effect of black seed oil (BSO) from Nigella sativa against Toxoplasma gondii Me49 strain...
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ژورنال
عنوان ژورنال: Parasitologists United Journal
سال: 2022
ISSN: ['2090-2646', '1687-7942']
DOI: https://doi.org/10.21608/puj.2022.149674.1175