THE THERAPEUTIC ANGIOGENESIS AND SYSTEMIC ENDOTHELIAL TONE
نویسندگان
چکیده
منابع مشابه
Therapeutic angiogenesis using vascular endothelial growth factor.
Therapeutic angiogenesis using vascular endothelial growth factor can reduce tissue ischemia by simulating the natural process of angiogenesis. Vascular endothelial growth factor not only stimulates endothelial cells to proliferate and migrate, but also mobilizes endothelial progenitor cells and achieves vascular protection. Besides direct administration of angiogenic proteins, plasmids and vir...
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Clinically approved therapies that target angiogenesis in tumors and ocular diseases focus on controlling pro-angiogenic growth factors in order to reduce aberrant microvascular growth. Although research on angiogenesis has revealed key mechanisms that regulate tissue vascularization, therapeutic success has been limited owing to insufficient efficacy, refractoriness and tumor resistance. Emerg...
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Evidence continues to accumulate on the importance of NO in angiogenesis.1–7 A number of angiogenic substances, including vascular endothelial growth factor (VEGF), stimulate production of NO in endothelial cells.8,9 In vivo biosynthesis of NO is essential for angiogenesis induced by tissue ischemia.3 Angiogenesis is severely impaired in ischemic hindlimb of endothelial NO synthase (eNOS)defici...
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Amid the criticisms levied at gene therapy researchers recently, the positive (yet preliminary) advances in therapies designed to elicit angiogenesis for the treatment of ischemic vascular disease, such as the current report by Vale and colleagues,1 are a breath of fresh air for cardiovascular specialists and their patients. Although therapeutic angiogenesis is still in its nascent stages (and ...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2010
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(10)61558-6