The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas is a CpG-type translocation, but the t(11;18)(q21;q21)/API2-MALT1 translocation in MALT lymphomas is not
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منابع مشابه
The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas is a CpG-type translocation, but the t(11;18)(q21;q21)/API2-MALT1 translocation in MALT lymphomas is not.
In a recent issue of Blood, Murga Penas et al identified a novel cluster region on MALT1 from t(14;18)(q32;q21) IGH-MALT1 translocations in MALT lymphomas, which bears many similarities to the bcl-1 major translocation cluster (MTC) from mantle cell lymphomas and the bcl-2 major breakpoint region (MBR) from follicular and diffuse large B-cell lymphomas.1 We have previously reported that pro-B/p...
متن کاملt(11;18)(q21;q21) is the most common translocation in MALT lymphomas.
BACKGROUND Low grade malignant lymphomas arising from mucosa associated lymphoid tissue (MALT) represent a distinct clinicopathological entity. The cytogenetic findings and molecular genetics of MALT lymphomas remain minimally defined. Cytogenetic studies infrequently constitute part of the diagnostic work-up of MALT lymphomas, most commonly due to small biopsy size and their extranodal localiz...
متن کاملThe t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas contains templated nucleotide insertions and a major breakpoint region similar to follicular and mantle cell lymphoma.
The t(14;18)(q32;q21) involving the immunoglobulin heavy chain locus (IGH) and the MALT1 gene is a recurrent abnormality in mucosa-associated lymphoid tissue (MALT) lymphomas. However, the nucleotide sequence of only one t(14;18)-positive MALT lymphoma has been reported so far. We here report the molecular characterization of the IGH-MALT1 fusion products in 5 new cases of t(14;18)-positive MAL...
متن کاملClinicopathologic Study of Chromosomal Aberrations in Ocular Adnexal Lymphomas of Korean Patients
PURPOSE The incidence and clinical correlation of MALT1 translocation and chromosomal numerical aberrations in Korean patients with ocular adnexal mucosa associated lymphoid tissue (MALT) lymphoma have not yet been reported. We investigated the incidence and clinicopathologic relationship of these chromosomal aberrations in ocular adnexal MALT lymphomas in a Korean population. METHODS Thirty ...
متن کاملTargeting Lymphomas Through MALT1 Inhibition
Diffuse large B-cell lymphoma (DLBCL), the most common form of non-Hodgkin Lymphoma, comprises a heterogeneous group of diseases that can be classified into at least three different entities with distinct gene expression signatures. Among these, the activated B cell-like (ABC)-DLBCLs are the most resistant to current standard immune-chemotherapy regimens [1]. Development of novel targeted thera...
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ژورنال
عنوان ژورنال: Blood
سال: 2010
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2010-01-265157