The Synthetic Scaffolds for Ventral Hernia Repair: Perspectives for Regenerative Surgery—Systematic Review

Abstract Ventral hernia (VH) frequently affects patients after abdominal surgery. The use of a mesh is often recommended. Different materials are described, from synthetic non-resorbable meshes to biological meshes. New generation meshes, also named scaffolds, aim combine the advantages both materials. this review provide an overview cytological, histological, biomechanical, and clinical outcomes newest resorbable scaffolds in VH repair, based on experimental studies pre-clinical setting. A systematic was conducted according Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines Assessing Methodological Quality (AMSTAR) guidelines. Only were included. Outcome parameters building technique, vitro cytocompatibility, vivo histocompatibility, biomechanical analysis, outcomes. articles included nine. total number cases treated 257. Materials analyzed electrospun silk fibroin (SF)/poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) hybrid biodegradable polyester poly-ε-caprolactone (PCL) form nanofibers, poly-4-hydroxybutyrate (P4HB), nanofibrous polylactic acid (PLA) scaffold with polypropylene (PP) material generate sandwich-like mesh, collagen sponge (CS) group, (HS) containing CS poly-L-lactide (PLLA), + bone marrow (HSBM). Resorbable new, safe, surgical treatment or prevention ventral animal models. Scaffolds should be tested contaminated field emergency use. Rigorous schematic indications data collection needed improve quality order definitively clarify pathway involved inflammatory induced response.