The surgically denervated, transplanted human heart.
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چکیده
منابع مشابه
The surgically denervated, transplanted human heart.
In this issue of Circulation, Regitz et all provide evidence that the transplanted human heart remains denervated for as long as 5 years after transplantation. These authors measured myocardial catecholamines in right ventricular septal endomyocardial biopsies taken from 24 orthotopically transplanted hearts and found measurable norepinephrine levels in only two samples, both of which were from...
متن کاملElectrophysiological Studies In the Denervated Transplanted Human Heart
To date, no studies have documented the conduction characteristics of the atrioventricular conduction system in the transplanted human heart. Three patients who had undergone cardiac transplantation 1—2 years previously formed the basis of this study. All were functional class I symptomatically and had normal hemodynamics and coronary arteriograms at the time of study. Each patient was in sinus...
متن کاملElectrophysiological effects of edrophonium in the innervated and the transplanted denervated human heart.
In order to determine the mechanism of action of edrophonium on the cardiac conduction system, we used His bundle recording and pacing techniques to examine the electrophysiological effect of edrophonium in 6 patients undergoing diagnostic evaluation for coronary artery disease and in 9 cardiac transplant recipients who were free of acute graft rejection. After control measures were made of sin...
متن کاملIsolated Presynaptic Inotropic j3-Adrenergic Supersensitivity of the Transplanted Denervated Human Heart In Vivo
Background. The regulation of contractility of the transplanted heart depends on circulating catecholamines resulting from cardiac denervation. Supersensitivity to circulating catecholamines may result from loss of presynaptic neuronal uptake or upregulation of postsynaptic (adrenergic receptors. Methods and Results. Dose-response curves using the j3-adrenergic receptor agonists isoprenaline (n...
متن کاملIsolated presynaptic inotropic beta-adrenergic supersensitivity of the transplanted denervated human heart in vivo.
BACKGROUND The regulation of contractility of the transplanted heart depends on circulating catecholamines resulting from cardiac denervation. Supersensitivity to circulating catecholamines may result from loss of presynaptic neuronal uptake or upregulation of postsynaptic beta-adrenergic receptors. METHODS AND RESULTS Dose-response curves using the beta-adrenergic receptor agonists isoprenal...
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ژورنال
عنوان ژورنال: Circulation
سال: 1990
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.82.2.658