The Surfactant Protein D (SP-D) Serum Levels in Limestone Mining Worker

Background: Limestone is sedimentation rocks consist of minerals calcite and aragonite, often contains silica, fossils, commonly used in building materials. mining workers are at high risk to pneumoconiosis. Surfactant protein D(SP-D) part collectin family, served as innate immune system pathogen recognition receptor (PRR). SP-D level were usually increased fibrotic lung disease. In this study, we sought the serum marker for early pneumoconiosis limestone worker Indonesia.Method: This study was cross-sectional observational study. Participant 65 workers, willing participate by signing informed consent, questionnaire, blood sample collected measure ELISA.Results: found that characteristic subjects dominated male with median age 42 years old last education mostly elementary school. Majority duration working <6 time a day >8 hours per day. The did not wear mask had normal weight group. ever smoker, mean (66.3±5.5ng/mL), slightly higher than subject. Smoking status, gender, hour correlated level.Conclusion: Although statistically significant, levels might be monitoring screening workers.