The stratum corneum comprises three layers with distinct metal-ion barrier properties
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چکیده
منابع مشابه
The stratum corneum comprises three layers with distinct metal-ion barrier properties
The stratum corneum (SC), the outermost barrier of mammalian bodies, consists of layers of cornified keratinocytes with intercellular spaces sealed with lipids. The insolubility of the SC has hampered in-depth analysis, and the SC has been considered a homogeneous barrier. Here, we applied time-of-flight secondary ion mass spectrometry to demonstrate that the SC consists of three layers with di...
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Under normal circumstances, epidermis must be as impermeable as possible except for a small amount of water loss to hydrate the outer layers of the SC. Although all living cells require water to function, some “dead” cells also require water to be metabolically active. As it is the case of corneocytes, epidermis must retain sufficient water to (a) hydrate the outer layers of the SC to maintain ...
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Water sorption is important for the overall structure and function of keratinized tissues such as the human epidermal stratum corneum (SC). In this study we report on a gravimetric method for studying sorption properties of human SC, both from heel and female breast skin. Changes in mass were measured as the relative humidity was altered in steps under controlled environmental conditions. The p...
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Reinhold Dauskardt Stanford University, Professor Materials Sciences and Engineering The stratum corneum (SC) is the outermost layer of the skin. Its process of reneweal is regulated by various mechanisms, including chemical and structural gradients through the SC thickness. In this study, an in vitro mechanics approach for studying the delamination behavior of SC in the direction perpendicular...
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To maintain a constant thickness of the stratum corneum the desquamation rate and the de novo production of corneocytes is delicately balanced. Using a plantar stratum corneum model we have obtained evidence that proteolysis is a central event in the desquamation process. A number of regulatory mechanisms for desquamation have been postulated based on our findings.
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2013
ISSN: 2045-2322
DOI: 10.1038/srep01731