The Sterile Inflammatory Response

Sterile Cell Death Stimulates the Inflammatory Response to Identification of the Cellular Sensor That

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome.

Dying cells are capable of activating the innate immune system and inducing a sterile inflammatory response. Here, we show that necrotic cells are sensed by the Nlrp3 inflammasome resulting in the subsequent release of the proinflammatory cytokine IL-1beta. Necrotic cells produced by pressure disruption, hypoxic injury, or complement-mediated damage were capable of activating the Nlrp3 inflamma...

Uric acid promotes an acute inflammatory response to sterile cell death in mice.

Necrosis stimulates inflammation, and this response is medically relevant because it contributes to the pathogenesis of a number of diseases. It is thought that necrosis stimulates inflammation because dying cells release proinflammatory molecules that are recognized by the immune system. However, relatively little is known about the molecular identity of these molecules and their contribution ...

The Inflammatory Response

Inflammation, which constitutes the body’s response to injury, is characterized by a series of events where several different cell types are playing distinct roles. Proteinase-activated receptors (PARs) are expressed in all the cell types that are involved in inflammatory processes. The expression of PARs is up-regulated during inflammatory processes. Activation of PARs can lead to inflammation...

IL-1 family cytokines trigger sterile inflammatory disease

Inflammation plays vital roles in protective responses against pathogens and tissue repair, however, improper resolution of inflammatory networks is centrally involved in the pathogenesis of many acute and chronic diseases. Extensive advances have been made in recent years to define the inflammatory processes that are required for pathogen clearance, however, in comparison, less is known about ...