The standard addition method and its validation in forensic toxicology

نویسندگان

چکیده

Abstract Purpose In the quantitative forensic toxicological analyses using instruments, major methods to be employed are conventional matrix-matched calibration method (MMCM). However, nowadays, needs for standard addition (SAM) increasing. spite of this situation, there no reports guidelines validations SAM. review, principle, how perform it, advantages, disadvantages, reported application data, and details validation procedures SAM described. Methods Various databases such as SciFinder, Google Scholar were utilized collect relevant referring The long experiences our research group on also included in review. Results Although experimental much more laborious than those MMCM, is essential quantify target xenobiotic(s) special matrices human solid tissues or biles, which remarkably interfere with usual analyses. have been proposed cases absence blank matrices. Conclusions To knowledge, first presentation detailed procedure its validation, will facilitate use toxicology. Especially new simple proposed.

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ژورنال

عنوان ژورنال: Forensic Toxicology

سال: 2021

ISSN: ['1860-8965', '1860-8973']

DOI: https://doi.org/10.1007/s11419-021-00585-8