The spleen contributes importantly to myocardial infarct exacerbation during post-ischemic reperfusion in mice via signaling between cardiac HMGB1 and splenic RAGE
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چکیده
منابع مشابه
Protective effect of natural honey applied during ischemia and reperfusion on infarct size in ischemic heartheart
Introduction: In the current study, protective effect of natural honey applied during ischemia/reperfusion (I/R) was studied on infarct size in ischemic heartheart. Methods: Ischemic hearthearts (n=8 per group) were mounted on a Langendorff apparatus at constant pressure then subjected to 30 min regional ischemia followed by 120 min reperfusion. In control group, the hearts were perfused by ...
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High-mobility group box 1 (HMGB1), a nuclear factor released extracellularly as an inflammatory cytokine, is an endogenous ligand for Toll-like receptor 4 (TLR4). TLR4 activation mediates kidney ischemia-reperfusion injury (IRI), but whether HMGB1 contributes to IRI is unknown. Here, treating wild-type mice with neutralizing anti-HMGB1 antibody protected them against kidney IRI, evidenced by lo...
متن کاملSplenic Infarct Due to Wandering Spleen in anAdult Patient
We present the case of an eighteen years old woman with the maturational disorder who went to the emergency area because of abdominal pain, focused on the left iliac fossa, fever and vomiting, since four days ago. The blood test showed 15.000 leukocytes, with 81% of neutrophils and PCR, 154. On the physical exploration, a mass on the left quadrant was noticed and positive peritonism signs. The ...
متن کاملActivated platelets contribute importantly to myocardial reperfusion injury.
Platelets become activated during myocardial infarction (MI), but the direct contribution of activated platelets to myocardial reperfusion injury in vivo has yet to be reported. We tested the hypothesis that activated platelets contribute importantly to reperfusion injury during MI in mice. After 30 min of ischemia and 60 min of reperfusion, P-selectin knockout mice had a significantly smaller ...
متن کاملThe alternative crosstalk between RAGE and nitrative thioredoxin inactivation during diabetic myocardial ischemia-reperfusion injury.
The receptor for advanced glycation end products (RAGE) and thioredoxin (Trx) play opposing roles in diabetic myocardial ischemia-reperfusion (MI/R) injury. We recently demonstrated nitrative modification of Trx leads to its inactivation and loss of cardioprotection. The present study is to determine the relationship between augmented RAGE expression and diminished Trx activity pertaining to ex...
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ژورنال
عنوان ژورنال: Basic Research in Cardiology
سال: 2016
ISSN: 0300-8428,1435-1803
DOI: 10.1007/s00395-016-0583-0