منابع مشابه
Hypothyroidism Enhances Tumor Invasiveness and Metastasis Development
BACKGROUND Whereas there is increasing evidence that loss of expression and/or function of the thyroid hormone receptors (TRs) could result in a selective advantage for tumor development, the relationship between thyroid hormone levels and human cancer is a controversial issue. It has been reported that hypothyroidism might be a possible risk factor for liver and breast cancer in humans, but a ...
متن کاملMalignant Meningioma with Lumbar Spinal Metastasis (a case report)
Meningioma is considered as a benign central nervous system tumor that accounts for approximately 18% of all brain tumors. About 5% of meningioma tumors are malignant and have more aggressive clinical signs and worse prognosis compared to benign tumors. Extracranial metastasis of meningioma is rare but in the case of occurrence, it is more prevalent in lung, liver and lymph nodes. Osseous metas...
متن کاملSpinal Intradural Metastasis
Spinal cord tumours account for about 15% of central nervous system neoplasms. Intramedullary tumours arise within the substance of the spinal cord, whereas extramedullary tumours are extrinsic to the cord. About two thirds of spinal cord tumors in adults are extramedullary in location, among which nerve sheath tumors, meningiomas and Filum terminale ependymomas account for the most. Metastatic...
متن کاملTGFβ signaling is necessary for carcinoma cell invasiveness and metastasis
BACKGROUND Invasive growth of epithelial tumor cells, a major cause of death from cancer in humans, involves loss of epithelial polarity and dedifferentiation. Transforming growth factor beta (TGFbeta) is regarded as a major tumor suppressor during early tumor development because it inhibits cell-cycle progression and tumor growth. Many dedifferentiated, late-stage tumors are resistant to growt...
متن کاملHeparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis.
BACKGROUND Heparanase is an endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix and basement membrane. Expression of the heparanase gene is associated with the invasive, angiogenic, and metastatic potential of diverse malignant tumors and cell lines. We used gene-silencing strategies to evaluate the role of heparanase in malignancy and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Spine
سال: 2020
ISSN: 0362-2436,1528-1159
DOI: 10.1097/brs.0000000000003823